U.S. Protein Expression Market

Industry Overview

The U.S. Protein Expression Market is expected to grow at a CAGR of 11.8% during the forecast period with its market size predicted to reach USD 3.2 billion by 2030. The U.S. protein expression market is primarily driven by the factors such as the increasing prevalence of chronic diseases, increasing investment for recombinant protein expression, advancement in technology for expression systems, increasing geriatric population, and robust growth of the life sciences industry in the country. Prokaryotic expression systems and mammalian cell expression systems are the major contributors to the protein expression industry in the region.

Market Segmentation

Insight by Product & Services

Based on product & services, protein expression market is categorized into expression vectors, competent cells, reagents, instruments, and services. Reagents hold the largest share in the U.S. market. Reagents are the key component for the successful protein expression and with the increasing number of research and development activities for protein biologics in the life sciences industry; the demand for reagents is anticipated to increase significantly.

Insight by Systems

Based on systems, the market is segmented into prokaryotic expression systems, yeast expression systems, cell-free expression systems, mammalian cell expression systems, algal-based expression systems, and insect cell expression systems. Among the various systems being used in the market, the prokaryotic expression system holds the largest share in the U.S. protein expression market. Prokaryotic expression systems are further categorized into Escherichia coli systems and other prokaryotic expression systems. The largest share of prokaryotic expression system is due to the cost-effectiveness, as it is less expensive over other available categories; and the various applications of E. coli systems in research and industrial applications.

Yeast expression system market is further categorized into saccharomyces systems, K. lactis systems, Pichia systems, and others. Among different types of mammalian cell expression systems, Chinese hamster ovary systems are the most commonly used expression system. Similarly, among insect cell expression systems, baculovirus systems witness the largest demand in the market.

Insight by Application

Based on application, the market is categorized into therapeutics, research, and industries. The increasing number of chronic diseases on a global level led to the application of protein expression majorly in finding therapy for chronic diseases. Also, the increasing number of life science and biopharmaceutical industries also adds to the largest contribution of therapeutics category to the protein expression market. Other key applications include research purposes and commercial productions of proteins in industries.

Insight by End User

Based on end users, the market is segmented into academic research institutes, contract research organizations, pharmaceutical and biotechnology companies, and others. Pharmaceutical and biotechnology companies are the largest end user in the U.S. protein expression market. This is primarily due to the large production of recombinant proteins for therapeutics, and the growing advancement in technology with respect to protein research. The highest demand for protein expression products and services is anticipated from CROs during the forecast period.

U.S. Protein Expression Market Report Coverage

Report Metric	Details
Historical Period	2018 - 2023
Base Year Considered	2024
Forecast Period	2025 - 2030
Market Size in 2023	U.S.D.  xx.x Billion
Revenue Forecast in 2030	U.S.D.  3.2 Billion
Growth Rate	11.8%
Segments Covered in the Report	By Product & Services, By System, By Application and By End User
Report Scope	Market Trends, Drivers, and Restraints; Revenue Estimation and Forecast; Segmentation Analysis; Impact of COVID-19; Companies’ Strategic Developments; Market Share Analysis of Key Players; Company Profiling
Regions Covered in the Report	U.S.

Industry Dynamics

Growth DriversChallenges

The increasing prevalence of chronic diseases, increasing funding for recombinant protein expression from government and non-government organizations, advancement in technology for expression systems, increasing geriatric population, and robust growth of the life sciences industry in the country are the primary growth drivers for the U.S. protein expression industry. Different government and non-government organizations are funding investment for the development of protein biologics. Technological advancements such as microfluidics have advanced the approach of protein expression system such as a cell-free expression system. Cell-free expression systems provide a very high yield of proteins are being proved efficient for the development of protein biologics.

The high cost of reagents and equipment, complexities associated with purification of proteins are the key challenges faced by the U.S. protein expression industry.

Competitive Insight

New England Biolabs is an American life sciences company which produces and supplies recombinant and native enzyme reagents for life science research. It also provides products and services supporting genome editing, synthetic biology and next-generation sequencing.

Thermo Fisher Scientific Inc. is an American-headquartered company and global supplier of analytical instruments, specialty diagnostics, laboratory, life sciences solutions, pharmaceutical and biotechnology services.

Some of the key players operating in the U.S. protein expression market are New England Biolabs, Inc., Thermo Fisher Scientific Inc., QIAGEN N.V., Takara Bio Inc., Lonza Group Ltd., Merck KGaA, Promega Corporation, Genscript Biotech Corporation, Agilent Technologies Inc., and Bio-Rad Laboratories, Inc.

Recent Developments by Key Players

Bio-Rad Laboratories, Inc. is a global leader in life science research and clinical diagnostics products had launched validated antibodies for rare cell and circulating tumor cell (CTC) enumeration. These antibodies are specific to CTC surface markers to enable the sensitive and specific identification of target cell populations, enhancing the study of tumor heterogeneity and disease progression at various stages.

Thermo Fisher Scientific enlarged its Millersburg, Pennsylvania, bioprocessing manufacturing site plant to produce essential components for the creation of new and current biologics and vaccines.

The U.S. Protein Expression Market report offers a comprehensive market segmentation analysis along with an estimation for the forecast period 2025–2030.

Segments Covered in the Report

• By Product & Services
  • Expression vectors
  • Reagents
  • Competent cells
  • Instruments
  • Services
• By Systems Channel
  • Prokaryotic expression systems
    • E. coli systems
    • Others
  • Yeast expression systems
    • Saccharomyces systems
    • K. Lactis systems
    • Pichia systems
    • Others
  • Mammalian cell expression systems
    • Chinese hamster ovary system
    • Others
  • Cell-free expression systems
  • Algal-based expression systems
  • Insect cell expression systems
    • Baculovirus system
    • Others
• By Application
  • Therapeutics
  • Research
  • Industrial
• By End-User 
  • Academic research institutes
  • Contract research organizations
  • Pharmaceutical and biotechnology companies
  • Others

PRIMARY RESEARCH INTERVIEWS - BREAKDOWN

1.       Research Overview

1.1.    The Report Offers

1.2.    Market Coverage

1.2.1.By Product & Services

1.2.2.By System

1.2.3.By Application

1.2.4.By End User

1.3.    Research Phases

1.4.    Limitations

1.5.    Market Size Estimations and Forecast

1.5.1.Data Sources

1.5.1.1. Primary Research

1.5.1.2. Secondary Research

1.5.2.Methodology

1.5.2.1. Data Exploration

1.5.2.2. Forecast Parameters

1.5.2.3. Data Validation

1.5.2.4. Assumptions

1.5.3.Study Period & Data Reporting Unit

2.       Executive Summary

3.       Market Definition

3.1.    By Product & Services

3.1.1.Expression vectors

3.1.2.Reagents

3.1.3.Competent cells

3.1.4.Instruments

3.1.5.Services

3.2.    By Systems

3.2.1.Prokaryotic expression systems

3.2.1.1. E. coli systems

3.2.1.2. Others

3.2.2.Yeast expression systems

3.2.2.1. Saccharomyces systems

3.2.2.2. K. Lactis systems

3.2.2.3. Pichia systems

3.2.2.4. Others

3.2.3.Mammalian cell expression systems

3.2.3.1. Chinese hamster ovary system

3.2.3.2. Others

3.2.4.Cell-free expression systems

3.2.5.Algal-based expression systems

3.2.6.Insect cell expression systems

3.2.6.1. Baculovirus system

3.2.6.2. Others

3.3.    By Application

3.3.1.Therapeutics

3.3.2.Research

3.3.3.Industrial

3.4.    By End User

3.4.1.Academic research institutes

3.4.2.Contract research organizations

3.4.3.Pharmaceutical and biotechnology companies

3.4.4.Others

4.       Industry Overview

4.1.    Industry Dynamics

4.1.1.Market Growth Drivers

4.1.2.Market Growth Restraints

4.1.3.Key Market Trends

4.1.4.Major Opportunities

4.2.    Industry Ecosystem

4.2.1.Porter’s Five Forces Analysis

4.2.2.Recent Development Analysis

4.2.3.Value Chain Analysis

4.3.    Competitive Insight

4.3.1.Competitive Position of Industry Players

4.3.2.Market Attractive Analysis

5.       U.S. Market Estimate and Forecast

5.1.    By Product & Services

5.2.    By Systems

5.3.    By Application

5.4.    By End User

6.       Company Profiles

6.1.    New England Biolabs, Inc.

6.1.1.Snapshot

6.1.2.Overview

6.1.3.Offerings

6.1.4.Financial Insight

6.1.5.Recent Developments

6.2.    Thermo Fisher Scientific Inc.

6.2.1.Snapshot

6.2.2.Overview

6.2.3.Offerings

6.2.4.Financial Insight

6.2.5.Recent Developments

6.3.    QIAGEN N.V.

6.3.1.Snapshot

6.3.2.Overview

6.3.3.Offerings

6.3.4.Financial Insight

6.3.5.Recent Developments

6.4.    Takara Bio Inc.

6.4.1.Snapshot

6.4.2.Overview

6.4.3.Offerings

6.4.4.Financial Insight

6.4.5.Recent Developments

6.5.    Lonza Group Ltd.

6.5.1.Snapshot

6.5.2.Overview

6.5.3.Offerings

6.5.4.Financial Insight

6.5.5.Recent Developments

6.6.    Merck KGaA

6.6.1.Snapshot

6.6.2.Overview

6.6.3.Offerings

6.6.4.Financial Insight

6.6.5.Recent Developments

6.7.    Promega Corporation

6.7.1.Snapshot

6.7.2.Overview

6.7.3.Offerings

6.7.4.Financial Insight

6.7.5.Recent Developments

6.8.    Genscript Biotech Corporation

6.8.1.Snapshot

6.8.2.Overview

6.8.3.Offerings

6.8.4.Financial Insight

6.8.5.Recent Developments

6.9.    Agilent Technologies Inc.

6.9.1.Snapshot

6.9.2.Overview

6.9.3.Offerings

6.9.4.Financial Insight

6.9.5.Recent Developments

6.10. Bio-Rad Laboratories, Inc.

6.10.1.    Snapshot

6.10.2.    Overview

6.10.3.    Offerings

6.10.4.    Financial Insight

6.10.5.    Recent Developments

7.       Appendix

7.1.    Exchange Rates

7.2.    Abbreviations

Note: Financial insight and recent developments of different companies are subject to the availability of information in the secondary domain.

List of Tables

Table 1    Sources
Table 2    Study Periods
Table 3    Data Reporting Unit
Table 4    U.S. Protein Expression Market Size, by Product & Services, 2018 - 2023 (USD Billion)
Table 5    U.S. Protein Expression Market Size, by Product & Services, 2025 - 2030 (USD Billion)
Table 6    U.S. Protein Expression Market Size, by Systems, 2018 - 2023 (USD Billion)
Table 7    U.S. Protein Expression Market Size, by Systems, 2025 - 2030 (USD Billion)
Table 8    U.S. Prokaryotic Expression System Market Size, by Application, 2018 - 2023 (USD Billion)
Table 9    U.S. Prokaryotic Expression System Market Size, by Application, 2025 - 2030 (USD Billion)
Table 12 U.S. Mammalian Cell Expression System Market Size, by End-user, 2018 - 2023 (USD Billion)
Table 13 U.S. Mammalian Cell Expression System Market Size, by End-user, 2025 - 2030 (USD Billion)
Table 14 U.S. Insect Cell Expression System Market Size, by Product & Services, 2018 - 2023 (USD Billion)
Table 15 U.S. Insect Cell Expression System Market Size, by Product & Services, 2025 - 2030 (USD Billion)
Table 16 U.S. Protein Expression Market Size, by Systems, 2018 - 2023 (USD Billion)
Table 17 U.S. Protein Expression Market Size, by Systems, 2025 - 2030 (USD Billion)

Table 16 U.S. Protein Expression Market Size, by Application, 2018 - 2023 (USD Billion)
Table 17 U.S. Protein Expression Market Size, by Application, 2025 - 2030 (USD Billion)
Table 18 U.S. Protein Expression Market Size, by End-User, 2018 - 2023 (USD Billion)
Table 19 U.S. Protein Expression Market Size, by End-User, 2025 - 2030 (USD Billion)
Table 20 Snapshot – New England Biolabs, Inc.
Table 21 Snapshot – Thermo Fisher Scientific Inc.
Table 22 Snapshot – QIAGEN N.V.
Table 23 Snapshot – Takara Bio Inc.
Table 24 Snapshot – Lonza Group Ltd.
Table 25 Snapshot – Merck KGaA
Table 26 Snapshot – Promega Corporation
Table 27 Snapshot – Genscript Biotech Corporation
Table 28 Snapshot – Agilent Technologies Inc.
Table 29 Snapshot – Bio-Rad Laboratories, Inc.

List of Figures

Figure 1 Market Coverage
Figure 2 Research Phases
Figure 3 Secondary Soures for Different Parameters
Figure 4 Methodology
Figure 5 Data Mining & Exploration
Figure 6 Data Triangulation
Figure 7 Assumptions for Market Estimation and Forecast
Figure 8 Executive Summary
Figure 9 U.S. Protein Expression Market - Growth Drivers and Restraints
Figure 10 Porter’s Five Forces Analysis
Figure 11 Competitive Benchmark
Figure 12 U.S. Protein Expression Market Highlight
Figure 13 U.S. Protein Expression Market Size, by Product & Services, 2018 - 2030 (USD Billion)
Figure 14 U.S. Protein Expression Market Size, by Systems, 2018 - 2030 (USD Billion)
Figure 15 U.S. Prokaryotic Expression System Market Size, by Type, 2018 - 2030 (USD Billion)
Figure 16 U.S. Yeast Expression System Market Size, by Type, 2018 - 2030 (USD Billion)
Figure 17 U.S. Mammalian Cell Expression System Market Size, by Type, 2018 - 2030 (USD Billion)
Figure 18 U.S. Insect Cell Expression System Market Size, by Type, 2018 - 2030 (USD Billion)
Figure 19 U.S. Protein Expression Market Size, by Application, 2018 - 2030 (USD Billion)
Figure 20 U.S. Protein Expression Market Size, by End-User, 2018 - 2030 (USD Billion)